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- E-Pak Process Scale Adsorbent Cartridges for Pharmaceutical Processing. Replacement for loose powdered activated carbon (PAC). For adsorption of precious metals and organic impurities
Tel: 800-249-1990 or 302-731-1700
Ecosorb® Multi-Functional Purification Media
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E-Pak® Process Scale Adsorbent Cartridges
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E-Pak® Process Scale Adsorbent Cartridges for Pharmaceutical Processing

E-Pak® cartridges are radial flow adsorption cartridges developed specified for pharmaceutical processing. Created with proprietary technology, E-Pak® cartridges provide the rapid kinetics of fine particle adsorption at flow rates and capacities suitable for laboratory, pilot plant, and full-scale commercial operations. They are designed for use in both aqueous and organic solvent systems, and incorporate design features compatible with use in explosion proof environments.

  • Proven Cartridge Design Assures Simple, Reliable Adsorption Processes With Excellent Scalability from Bench Scale to Full Commercial Production
  • Fixed Porous Media Completely Eliminates Handling and Safety Issues Associated with Loose Carbon
  • Large Adsorption Capacity in a Small Foot Print Increases Product Recovery and Reduces Solvent Requirement.
  • RETROFIT KITS available to allow Cartridge use in most Existing Filter Housings

Applications: E-Pak® adsorbent cartridges are designed for the purification of API’s and intermediates dissolved in polar and non polar solvents. Primary applications include removal and recovery of catalyst, reaction-by-products and color from synthetic reaction mixtures and natural products. Compared to loose media, pre-packed columns and ventricular style filters Graver Process Scale Adsorbents provide important advantages including: Reduced process time, increased purity and recovery, improved safety, handling disposal and lower operating cost.

E-Pak® adsorbent cartridges are available in range of sizes and formulations (based on many of the adsorbent formulations in our Ecosorb® C-Series of adsorbents) to accommodate the broad range of processing requirements encountered over the typical API development cycle.

Graver supplies filter housings for the complete range of cartridge sizes and configurations available, and will also supply retrofit kits for many commonly used filter housings. Contact Graver for complete details.

Downloads:

» GTX 323 E-Pak® Process Scale Adsorbent Cartridge
» GTX 324 Operating Procedure for E-Pak® Lab-Scale Housing and Adsorbent Cartridges
» GTX 325 Pilot Plant and Commercial Scale Housings for E-Pak® Process Scale Adsorbent Cartridges (Coming soon – contact your Graver representative for our most recent information)
» GTX 327 E-Pak® Adsorbent Cartridge Selection Guide for Pharmaceutical Applications (Coming soon – contact your Graver representative for our most recent information)

E-Pak® Media and laboratory Scale Cartridges

E-PAK   
Formula*
Active Adsorbent Available Sizes Media  Weight
C-941 Carbon-Wood-Acid Activated Loose Media
5 cm Diameter X (1 ,10 &  25 cm High) Cartridges
100 grams
5, 50 & 125 grams respectively
C-944 Carbon-Coal Steam Activated
C-947 Carbon-Wood Acid Activated
C-950 Flash Silica
*Custom Formulations Available

E-Pak® Pilot Scale Cartridges

E-PAK Formula Active Adsorbent Available Sizes Media  Weight 
C-941 Carbon-Wood-Acid Activated 16.5 Diameter X  12.5 cm and 25 cm High Cartridges  with DOE or 222 O-ring Seal 0.85 Kg    
C-944 Carbon-Coal Steam Activated  
C-947 Carbon-Wood Acid Activated 1.7 Kg
C-950 Flash Silica

E-Pak® Commercial Scale Cartridges

E-PAK Formula   Active Adsorbent Available Sizes Adsorbent  Weight 
C-941 Acid Activated Carbon 16.5 Diameter X 50 cm High Cartridge with DOE or 222 O-ring Seal 3.4 Kg
C-944 Steam Activated Carbon
C-947 Acid Activated Carbon 16.5 Diameter X 100 cm High Cartridge with DOE or 222 O-ring Seal 6.8 Kg
C-950 Flash Chromatography Grade Silica

E-Pak®  Flow, Hydraulic Pressure Drop and Contact Time

Cartridge Size Flow Rate  Pressure Drop (∆P- ATM) with 1 cps fluid Contact Time (Minutes)
Lab Scale            (5cm D X 1, 5 & 10 cm H Cartridge) 7 - 37 - 75 ml/min 0.07 2.5’
Pilot & Commercial Scale(16.5 cm D X 12.5 25, 50, 100 cm H Cartridge) 0.95- 1.9 - 3.8 - 7.6  L/min 0.17 2.5’

E-Pak® Custom Cartridge Housings

# Cartridges Description Materials of Construction
1 10”or  20” housing dome,  T-Style , 222 O-ring Seal                            316L SS or Hasteloy® C-276 
3  20” or 40” housing dome, T-Style, 222 O-ring Seal
7  20”or 40” housing dome, T-Style, 222 O-ring Seal
12  30” or 40” housing dome, T-Style, 222 O-ring Seal

Filter Housing Options: ASME or PED Pressure Rated/Stamped, Conductive Casters, KALREZ® Gaskets, Type and Size of Inlet & Outlet, Wetted and Non Wetted Surface Finish.


Graver E-Pak® Radial Flow Adsorbent Cartridge



E-Pak® Adsorbent Cartridges



Laboratory Scale E-Pak® Housing



Graver Housing for E-Pak® Adsorbent Cartridges



E-Pak® 12 Cartridge Configuration

 
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