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Purification of Pharmaceutical API’s, Intermediates, and Fermentation Broths

Removal of reaction by-products, including color bodies and metals, is a critical step in producing high quality pharmaceuticals and intermediates. Ecosorb® multi-functional adsorbents are a family of highly efficient adsorbents combining the rapid kinetics of fine particles with excellent filtration characteristics.

Ecosorb powders can be used in a stirred reactor, or as a precoat or deep bed operating mode, where the adsorbent is added directly to the filter, eliminating contamination of the reaction vessel. Formulations include moist versions, suitable for aqueous systems, as well as low-moisture versions suitable for organic solvents. Since each reaction/solvent system is unique, Graver provides a “sample kit”, containing a broad range of adsorbent types for screening specific applications.

Application Notes

GTX 304: Ecosorb Products for Pharmaceutical Purification

Data Sheets

C-906 Data Sheet - color, reaction by-products (Coming soon – contact your Graver representative for our most recent information)

C-910 Data Sheet - PM catalysts, color, reaction by-products (Coming soon – contact your Graver representative for our most recent information)

C-941 Data Sheet - PM catalysts

C-944 Data Sheet - PM catalysts (Coming soon – contact your Graver representative for our most recent information)

C-950 Data Sheet - Color, Polar contaminants (Coming soon – contact your Graver representative for our most recent information)

C-952 Data Sheet - Color, Polar contaminants (Coming soon – contact your Graver representative for our most recent information)s

C-971 Data Sheet - Divalent heavy metals cations

C-981 Data Sheet - Color, contaminants from fermentation broth, Anionic contaminants

Graver’s new Ecosorb PAK® Process Scale adsorbent cartridges are available in equivalent formulations to many of the carbon and silica based C-Series Ecosorb products. E-PAK® adsorbent cartridges can be operated in Graver-supplied housings or in many commonly used industrial style filter housings, either directly, or with retrofit kits from Graver. Ecosorb PAK adsorbent cartridges improve product recovery, eliminate reactor vessel and filter clean up, greatly simplify adsorptive purification operations, and improve safety and handling. Contact Graver for further details.

E-Pak® Process Scale Adsorbent Cartridges – Product Overview


Graver E-Pak® Radial Flow Adsorbent Cartridge


E-Pak® Adsorbent Cartridges


Laboratory Scale E-Pak® Housing


© Graver Technologies, 2008.

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